Biosoluble ceramic fiber reinforced poly(L-lactic acid) bone scaffold: degradation and bioactivity

Abstract Poly (l-lactic acid) (PLLA) exhibits great potential as a kind of scaffold material for bone defect repair because its good biocompatibility and processability, while the too slow degradation rate hinders further application. In this study, biosoluble ceramic fiber (BCF) was introduced into PLLA matrix, PLLA/BCF composite manufactured by selective laser sintering (SLS). It observed that water contact angle decreased from 87.4° to 61.1° with increasing content BCF, pH value raised 6.6 7.8, molecular weight after immersion 4 weeks. The mechanism acceleration dissolution BCF not only released OH ? solution environment produced alkaline microenvironment, but also formed capillary channels on interface between beneficial infiltration hydrophobic which contributed both surface in interior matrix. Besides, Ca 2+ , Si Mg simultaneously absorbed PO 3? environment, contributing formation bonding host bone. addition, improved mechanical capacities via breakage, debond separation, so on.